Patients with BAG3 low/CXCR4 high demonstrated worse overall survival compared with BAG3 low/CXCR4 low, as well as patients with BAG3 low/CXCR4 high and those with BAG3 high/CXCR4 high demonstrated similar overall survival (Figure 7f), indicating that CXCR4 also exerted oncogenic function independent of BAG3 in breast cancer. This evidence concerns the gene CXCR4 and breast carcinoma.