Our in-depth study demonstrated that in GBM cells, where mTORC2 was activated, the hedgehog pathway also activated as evidenced by upregulation of Gli1, Gli2FL, Ptch1 and the downstream target genes (VEGF, Slug, Snail, Cyclin D1, Cyclin D2, Cyclin E). Here, GLI1 is linked to glioblastoma.