Glioblastoma multiforme (GBM) represents the most common form of malignant brain tumors in adults with extremely low survival rate.1 Deregulation of mTORC2 signaling is one of the main mechanisms in GBM formation.2 Hyperactivation of mTORC2 with Rictor overexpression was found to cause GBM.3, 4 mTORC2 has been linked with several metabolic reprogramming activities and is a major regulatory molecule.5, 6. Here, RICTOR is linked to glioblastoma.