NFKB1 and cancer: Defective autophagy may contribute to inflammation via the NF-κB pathway in cancer and other diseases.53 Specifically, p62 directly stimulates the NF-κB pathway by interacting with TRAF6.54 In M2 macrophages, autophagy selectively degrades NF-κB RELA/p65, and thus reduces the production of proinflammatory cytokines.55 In contrast, impaired autophagosome clearance and the consequent p62 accumulation might lead to the induction of proinflammatory responses.