As a sponge, lncRNAs is often reported to relieve one specific target of miRNA, for example, Hotair, and H19 have been reported to compete with miR-331-3p and miR-138/miR200a to regulate expressions of Her2 and vimentin/ZEB, respectively.36, 37 However, integrative analysis revealed that sponge regulation by lncRNA had a widespread influence on the expression of protein-coding cancer driver genes, which was not a simple one-to-one.32 LncRNA might sponge several miRNAs or single miRNA that targets multiple protein-coding genes, thus revert multiple genes expressions. The gene discussed is ZEB1; the disease is cancer.