Metastasis associated lung adenocarcinoma transcript 1 (MALAT1), which was originally discovered in association with metastatic behavior of non small cell lung cancer, has been reported to promote metastasis in PDAC.8, 9 LncRNA ROR (Regulator of Reprogramming) was found to upregulate CSC maker Nanog or EMT inducer ZEB1, leading to increased pancreatic cancer invasion and tumorigenesis.10, 11 LncRNA H19, an imprinted gene was also found to promote PDAC cell invasion and migration by increasing HMGA2-mediated EMT through antagonizing let-7.12 This evidence concerns the gene ZEB1 and pancreatic neoplasm.