ZEB1 and familial pancreatic carcinoma: For examples, ZEB1 and ZEB2, the key regulators for EMT process, have been proven to maintain stemness properties,27 while stem cell maker Lin28 can induce EMT via downregulation of let-7.28 Our results and the work from others showed that pancreatic cancer cells accumulated EMT and stemness phenotypic cells while developing gemcitabine resistance (Figures 1 and 2).29, 30 Therefore, it is important to identify which factor could promote EMT and CSC formation and uncover the mechanistic role of such factor for the development of novel and targeted therapies.