LIN28A and cancer: MiR-145 could promote tumor progression by inhibiting Oct4, Lin28, Nanog, Sox2 and ZEB1 in different cancer models.17, 18, 19, 20 Overexpression of miR-145 resulted in downregulation of Oct4, Lin28, Nanog, Sox2 and ZEB1 in BxPC3-Gem cells (Figure 7a), confirming that miR-145 targets all these molecules in pancreatic cancer.