EPOR and Insulin resistance: On the other hand, although mice with EPOR expression restricted to hematopoietic tissue become obese and insulin-resistant, and have decreased levels of proopiomelanocortin in the hypothalamus [41], adipose tissue-specific disruption of EPOR does not change (under the physiological levels of EPO) adipose expansion, adipocyte morphology, insulin resistance, inflammation, or angiogenesis in vivo [37].