The mRNA levels of Ocln were higher in both FRB and RB groups (p < 0.05 vs. control), whereas Cldn1 and Cldn4 levels were higher in the FRB group only (p < 0.05 vs. control) as shown in Figure 4A. In addition, Muc2 mRNA levels were found to be elevated in the FRB group (p < 0.05 vs. control), but not in the RB group (p > 0.05 vs. control) as shown in Figure 4B. In contrast, mRNA levels of the pro-inflammatory cytokine gene Il-17 were lower in the FRB group than in the control and RB groups (Figure 4C). The gene discussed is CLDN4; the disease is retinoblastoma.