CYP2E1 and acute kidney injury: To confirm whether oxidative stress is interrelated to the evolvement of cisplatin-induced AKI in vivo, the expression levels of NADPH oxidase enzyme Nox4, drug-metabolizing enzyme cytochrome P450 E1 (CYP2E1) and cytoprotective enzyme heme oxygenase-1 (HO-1) were examined.