GLS and schizophrenia: The global heterozygous Gls1 reduction impacts several DA dependent behaviors that underpin a schizophrenia resilience phenotype (Gaisler-Salomon et al., 2009b), characterized by an attenuated response to psychostimulant challenge, potentiated latent inhibition, procognitive effects (Hazan and Gaisler-Salomon, 2014), together with CA1 hippocampal hypoactivity inverse to the CA1 hyperactivity seen in patients with schizophrenia (Gaisler-Salomon et al., 2009a; Schobel et al., 2009).