Likewise, mutations in the snRNP components PRPF8, PRPF3, U2AF35, and SF3B1 cause diseases (e.g., retinitis pigmentosa for PRPF proteins, and myelodysplasia for U2AF35 and SF3B1) that are associated with broad changes in the production of splice variants (Chabot & Shkreta, 2016). Here, U2AF1 is linked to retinitis pigmentosa.