Jendrzejewski et al. 28 reported that the expression of a non-coding RNA gene named papillary thyroid carcinoma susceptibility candidate 3 (PTCSC3) located near MBIP/NKX2-1 was downregulated in thyroid tumour tissue and the risk allele (T) was associated with the profound suppression, which implies that PTCSC3 could have some role as a tumour suppressor in DTC. This evidence concerns the gene NKX2-1 and neoplasm.