In the case of PM/DM, serum autoantibodies can be divided into myositis-specific antibodies (MSAs) (anti-Jo1, anti-PL-7, anti-PL-12, anti-EJ, anti-OJ, anti-Mi-2, anti-SRP, anti-KS, anti-TIF1γ/α (anti-155/140), anti-TIF1β, anti-MJ/NXP-2, anti-MDA5/CADM-140, anti-SAE) and myositis-associated antibodies (MAAs) (anti-PM-Scl, anti-Ku, anti-U1-RNP, anti-U1/U2-RNP, anti-U3-RNP) [64]. This evidence concerns the gene U1 and myositis disease.