Depletion of FANCM has been reported to have effects on both the FA pathway efficiency and tumorigenesis: FANCM deficient mouse embryonic fibroblasts displayed increased chromosomal breakage, residual FANCD2 monoubiquitination, and increased spontaneous sister chromatid exchanges, and the FANCM knockout mice had reduced overall and tumor-free survival [40]. The gene discussed is FANCM; the disease is neoplasm.