Several FA genes (FANCD1/BRCA2, FANCN/PALB2, FANCJ/BRIP1, FANCO/RAD51C, and FANCS/BRCA1) [5–11] are high- or moderate-risk breast or ovarian cancer susceptibility genes and previous studies have connected also heterozygous FANCM mutations with breast cancer predisposition [12–14]. This evidence concerns the gene PALB2 and ovarian cancer.