Importantly, in addition to describing the phenotypic consequences of manipulating cellular sdRNA-93 levels, the current study also describes a regulatory target of sdRNA-93, the sarcosine metabolism-related gene Pipox, whose expression has previously been shown to strongly correlate with specific breast cancer subtypes and prognosis.27 In summary, this work successfully identifies a specific sdRNA (sdRNA-93) contributor to breast cancer pathology further emphasizing the relevance of this relatively new form of noncoding RNA regulator to malignancy. Here, PIPOX is linked to breast carcinoma.