In conclusion, in models of Th-2 immune response stimulation, the intake of cocoa prevents the secretion of typical Th2-cytokines, the synthesis of IgE involved in mast cell degranulation, and also downregulates the IgE receptors in mast cells and intestinal mast cell activation, which are the cells responsible for the most allergy symptoms. The gene discussed is IGHE; the disease is allergic disease.