Genes of the major histocompatibility complex (Human Leucocyte Antigen-HLA) are perhaps the best risk markers for the development of T1D, In Caucasians, HLA Class II antigens, particularly DR4-DQ8, are associated with a high risk of T1D; however, the exact HLA types associated with disease vary among different ethnic groups [12]. This evidence concerns the gene TNFRSF10A and type 1 diabetes mellitus.