In a 6-month RCT in 44 patients with T2DM, Macauley et al. [82] reported that vildagliptin 50 mg twice daily significantly decreased plasma alanine aminotransferase (ALT) levels (from 27 to 20 IU/L, p < 0.001) and IHTG by 1H-MRS (from 7.3 % to 5.3 %, p = 0.001). Here, GPT is linked to type 2 diabetes mellitus.