In one study [42], withdrawal from therapy according to strict criteria on follow-up (achieving normal PRL, disappearance or shrinkage of ≥50 % of tumor size, and a 5 mm distance from the optic chiasm) was associated with recurrence rate of 36 % 18 months following CAB cessation and a higher recurrence rate (53.1 %) after a longer follow-up (24–96 months) period [27]. This evidence concerns the gene PRL and neoplasm.