Top significant (P < 0.001) diseases associate with the gene panel included ‘virus diseases’, ‘viremia’, ‘infection’, ‘HIV-1 infection’ and ‘inflammation’, and significant disease collections, as depicted by Pathway StudioTM, included ‘Dendritic Cell Activation in Systemic Lupus Erythematosus’ and ‘MAVS in Antiviral Innate Immune Response in Myocarditis’. The gene discussed is MAVS; the disease is HIV-1 infection.