It has been described that synergistic behavior of both variant alleles of C677T and A66G polymorphisms with alleles of other genes related to folate metabolism, such as MTR, glutamate carboxypetidase II (GCP II) and methionine synthase (MS), can influence the risk of coronary artery disease (CAD) in different populations (24-26). This evidence concerns the gene FOLH1 and coronary artery disorder.