In an experiment on 7,12-dimethylbenz[a]anthracene (DMBA) induced breast cancer in FNB/N type rats, it was revealed that DMBA resulted in higher expression of the genes involved in carcinogenesis, including c-myc and cyclin-D1, as well as activation of the NF-kB pathway. The gene discussed is NFKB1; the disease is breast cancer.