BMI1 and cancer: Recent studies reported that ethyl acetate extraction of JXY significantly inhibited hepatoma cell growth both in vitro and in the mouse xenograft model through arresting cancer cells at G0/G1 phase, inhibiting angiogenesis, and inducing cancer cell apoptosis, which may involve the suppression of the Bmi1 and Wnt/β-catenin signaling pathways [83].