For the treatment of colorectal cancer, berberine was mainly involved in inducing apoptosis and restraining inflammation, inhibiting tumor growth, inactivating Wnt/β-catenin signaling, promoting the generation of ROS, inhibiting arylamine N-acetyltransferase (NAT) activity and cyclooxygenase 2 (COX-2) expression [21]. Here, PTGS2 is linked to neoplasm.