Gonadotrophins (FSH/LH) and growth hormone (GH) deficiency are the most common pituitary hormone deficiencies, 76.4% (391 patients) and 72.1% (369 patients), respectively, followed by ACTH (352 patients, 68.8%) and TSH (346 patients, 67.8%) deficiencies (Figure 2). The gene discussed is BRD2; the disease is hypopituitarism.