We observed a positive correlation of baseline betatrophin concentrations with HOMA-IR (r = 0.39, p = 0.008), a negative correlation with Matsuda index (r = −0.31, p = 0.004), and a positive relationship with HOMA-B (r = 0.38, p = 0.01) (Figure 1), only in women with PCOS. This evidence concerns the gene ANGPTL8 and polycystic ovary syndrome.