In contrast, disseminated histoplasmosis occurred in IL-12Rβ1 deficiency (141), IFN-γR1 deficiency (146), and GOF STAT1 defect (161), but 7 out of 10 cases of histoplasmosis in hyper-IgE syndrome involved the aerodigestive tract only (175–182). The gene discussed is IFNGR1; the disease is histoplasmosis.