Although the NEIs cause inhibition of CRM1 in normal and tumor cell types, the downstream consequences of this inhibition are different to that of LMB, inducing cell cycle arrest (instead of apoptosis) in normal lung fibroblasts and apoptosis in p53 wild-type cancer models (HCT-116 colon model and SiHa cervical cancer) (Mutka et al., 2009). This evidence concerns the gene TP53 and cancer.