Chromosome Region Maintenance1 (CRM1) is therefore a promising cancer drug target, and the use of small molecule inhibitors of CRM1 for a variety of cancers has been reviewed in detail (Turner et al., 2012a, 2014; Gravina et al., 2014; Parikh et al., 2014; Senapedis et al., 2014; Tan et al., 2014; Das et al., 2015) and will not be discussed further. The gene discussed is XPO1; the disease is cancer.