The down-regulation of Bcl-2/Bax ratio has been also founded being accompanied by the activation of caspase family in the experiments on PAB-treated cancer cells (Xu et al., 2008; Yu et al., 2012; Yu B. et al., 2014; Zhao et al., 2012; Wang et al., 2013; Yao et al., 2016). Here, BCL2 is linked to cancer.