Our previous studies found that EMAP II could induce the apoptosis of rat C6 glioma cells through mitochondrial-mediated pathway (Liu et al., 2015), induce the autophagy of human GBM cells (Ma et al., 2015), and increase the BTB permeability by the opening of paracellular pathway and caveolae-mediated transcellular pathway (Xie et al., 2012; Li et al., 2014). This evidence concerns the gene AIMP1 and glioblastoma.