FAS and neoplasm: Endothelial-monocyte activating polypeptide II is defined as a tumor-derived pro-inflammatory cytokine that can induce endothelial cell apoptosis by up-regulating Fas-associated death domain and down-regulating Bcl-2, and can inhibit endothelial cell proliferation, vasculogenesis, and neovessel formation (Berger et al., 2000).