TRPV1 and Dry skin: In addition to its association with histamine-dependent acute itch, increased TRPV1 expression in the skin and DRG has been reported in multiple chronic itch diseases, such as dry skin, atopic dermatitis and prurigo nodularis (Miyamoto et al., 2005; Alenmyr et al., 2009; Yun et al., 2011).