The present conclusion is supported by previous studies showing secretion failures in exogenous (ANP.emd) and endogenous (cystatin C and thrombospondin 1) vesicular cargos in cultured astrocytes and neurons expressing presenilins carrying mutations linked to familial Alzheimer disease and incubated with Aβ (Ghidoni et al., 2007; Rama Rao et al., 2013; Stenovec et al., 2016). This evidence concerns the gene EMD and familial Alzheimer disease.