We selected three established disease-associated gene sets; psychiatric disorder-associated PsyGeNET gene sets (Gutierrez-Sacristan et al., 2015), ASD-associated Simons Foundation Autism Research Initiative (SFARI) gene set5, and broad human disease-associated DisGeNET gene sets (Piñero et al., 2017) and compared these gene sets with the 94 genes of Shank3-mTORC1 interactome. This evidence concerns the gene SHANK3 and psychiatric disorder.