SHANK3 and psychiatric disorder: We found that among the eight major classes of psychiatric disorders in the PsyGeNET, “BDs and related disorders” and “SCZ spectrum and other psychiatric disorders” were significantly associated with the 94 genes of Shank3-mTORC1 interactome (adjusted P = 0.000186 for both, hypergeometric test; Figures 4A,B and Supplementary Table S8).