HOTAIR is highly expressed in breast cancer, lung cancer, pancreatic cancer, hepatocellular carcinoma, gastric cancer, brain glioma and related to metastasis and poor prognosis of tumor, which strongly indicating HOTAIR plays carcinogenic role in the above mentioned cancer tissues (Gupta et al., 2010; Geng et al., 2011; Hajjari et al., 2013; Kim et al., 2013; Zhang et al., 2013; Zhuang et al., 2013). This evidence concerns the gene HOTAIR and breast cancer.