HOTAIR and central nervous system cancer: HOTAIR was highly expressed in malignant gliomas tissues or U87 and U251 cells, and silence of HOTAIR decreased the abilities of proliferation, migration, and invasion as well as promoted cell apoptosis in glioma cells, and these influences on the biological behavior of glioma cells were achieved through the competitive inhibition of HOTAIR on miR-326-mediated targeting combination with FGF1 (Ke et al., 2015).