Similarly, the African American Study of Kidney Disease and Hypertension trial including hypertensive blacks with a GFR of 20 to 65 ml/min/1.73 m2 and no other identified cause of kidney disease found that patients with elevated NT-pro-BNP had a 4 times higher hazard for cardiovascular events than those with undetectable levels [22]. Here, NPPB is linked to kidney disorder.