Most of the genetic forms of ALS are associated to mutations in genes encoding superoxide dismutase 1 (SOD1), TAR DNA binding protein of 43-kDa (TDP-43) and fused in sarcoma (FUS), or to hexanucleotide repeat expansions in chromosome 9 open reading frame 72 (C9ORF72)1. Here, FUS is linked to amyotrophic lateral sclerosis.