Staining a tissue microarray (TMA) containing 26 samples from patients with BPH and 72 samples from patients with prostate cancer confirmed that TSPAN1 protein is also expressed at significantly higher levels in prostate cancer patients compared to benign controls (p = 0.0081) (Fig. 2C) (further information on the clinical samples used in the TMA is given in Supplementary Table 2). Here, TSPAN1 is linked to Familial prostate cancer.