TSPAN1 and Familial prostate cancer: The data presented in this study are in contrast to a recent publication suggesting that decreased TSPAN1 is linked to prostate cancer progression and that TSPAN1 plays a negative role in prostate cancer cell proliferation and migration (which used a different antibody to detect TSPAN129), but are in agreement with studies in numerous other cancer types where upregulated TSPAN1 is linked to cancer progression, cell survival, proliferation, migration and invasion15, 17, 25–28, 50, 51, 53.