Third, influenza A virus (Hkx31; 105 PFU per mouse) infection in mice in vivo for 24 h resulted in greater increases in lung IFN-β, IL-1β, IL-6, and TNF-α mRNA (Fig. 8b), as well as serum (Fig. 8c) and lung IFN-β protein (Fig. 8d) in NOX2−/y mice. The gene discussed is TNF; the disease is infection.