SCARB1 and neural tube defect: In this work, our results show that cephalic defective neurulation in SR-BI-deficient embryos can be reduced by supplementing dams with folate or vitamin E. Although we cannot compare the effectiveness of each intervention due to the use of unique doses and different administration routes, our findings of vitamin E deficiency and NTD prevention in SR-BI null embryos support the idea that other nutrients besides folate need to be considered for the prevention of NTD, given the complex and heterogeneous aetiology of this condition.