KDM6A and neoplasm: Mutations in JmjC genes that have been directly linked to human pathology include deletion of KDM3B in myeloid leukemias7 and breast cancer8, deletion of KDM5D in 50% of prostate cancers9, inactivatiing somatic mutations in KDM6A in multiple tumor types10, association of KDM7B mutations with autism spectrum disorders11, and disruption of normal circadian rhythms in JMJD5 mutants12.