As CFTR is expressed in a large variety of tissues, the presently observed hypoxia-induced CFTR downregulation provides a missing link between micro-environmental signaling i.e. hypoxia, and intracellular signaling pathways, i.e. Wnt/β-catenin, leading to EMT process during physiological and/or pathological conditions, such as fibrosis and cancer. Here, CFTR is linked to cancer.