In the present study, we found that the five macrophage chemokines mentioned above but not the three neutrophil chemokines in sera from L. interrogans-infected mice and leptospirosis patients were significantly increased, while the VCAM-1, and E-selectin and P-selectin in the internal organ tissues of L. interrogans-infected mice, but not ICAM-1, were present at high expression levels. This evidence concerns the gene SELP and leptospirosis.