HMOX1 and type 1 diabetes mellitus: Indeed, the administration of HO-1 inducer compounds, such as cobalt protoporphyrin IX (CoPP) inhibits acute thermal nociception [9], inflammatory [10–12], visceral [11] as well as neuropathic pain induced by nerve injury, vincristine injection, or associated with type 1 diabetes in rodents [8, 13, 14].