We revealed an overexpression of BRG1 in HCC and demonstrated that down-regulation of BRG1 impairs proliferation along with the decreased expression of cyclin B and cyclin E. In addition, in line with a decreased invasive ability, a down-regulation of MMP7 was found upon knockdown of BRG1 expression. The gene discussed is CCNE1; the disease is hepatocellular carcinoma.