SFN-induced tumor cell growth suppression in pancreatic cancer was reported to be linked with Sonic hedgehog signaling, interaction with Hsp90, oxidative stress, induction of macroautophagy and inhibition of histone deacetylases (HDAC), enzymes that are expressed aberrantly in pancreatic cancer cells [13–16]. This evidence concerns the gene HDAC9 and familial pancreatic carcinoma.