In contrast under inflammatory conditions such as in psoriasis, the vast presence of inflammatory cytokines of the TH1/17 family, constitutively activates mTORC1 signaling via PI3-K/ Akt, which can not only be seen in human psoriasis [17, 28] but also in different psoriasis mouse models and PUVA treatment significantly inactivated the mTOR pathway in vitro and in vivo [29, 30]. This evidence concerns the gene AKT1 and psoriasis.