In addition to the differential methylation changes in the ANK1 gene in AD [11], recent EWAS studies also identified a number of other loci as being differentially methylated in disease (ABCA7, BIN1, CDH23, DIP2A, RHBDF2, RPL13, RNF34, SERPINF1 and SERPINF2). The gene discussed is RHBDF2; the disease is Alzheimer disease.