GGT is a stable serum molecule from liver, and high levels of serum GGT are indicative of hepatic or bile tract-associated diseases.[19] The mechanism underlying how HBV targets the hepatocytes, turns over, and excretes out of hepatocytes has been mostly elucidated in recent studies.[20–23] High level of hepatitis B virus replication is directly associated with the development of acute or chronic inflammation, fibrosis, cirrhosis, and HCC.[24,25] So, the expression of PCT is closely related to chronic virus hepatitis and liver function. Here, CALCA is linked to Cirrhosis.