ZEB1 and neoplasm: A key player in this process is the zinc‐finger E‐box‐binding homeobox factor 1 (ZEB1), a transcription factor whose aberrant upregulation in tumor cells is directly linked to loss of E‐cadherin, reduced cellular adhesion, increased invasiveness, changes in cell polarity, and metastasis development (Karihtala et al., 2013; Spaderna et al., 2008; Zhang et al., 2015).