As model system, we first assessed ZEB1, CD44, and LKB1 colocalization in two different breast cancer cell lines, the epithelial, luminal A subtype (MCF‐7) and the mesenchymal, metastatic type (MDA‐MB‐231), well representing the patients’ cohort in terms of primary tumor characteristics. The gene discussed is ZEB1; the disease is breast carcinoma.