REN and endothelial dysfunction: Pharmacologic approach is helpful because of endothelial dysfunction.Renin-angiotensin system blocker and calcium channel blocker may be good options intype 2 diabetes mellitus.21Pinheiro et al.22 have assessedthe effect of the antiplatelet drug clopidogrel in association or not withrosuvastatin (40 mg) on the levels of EMP and PMP in patients with stable coronarydisease on statins for at least three months.