ADPKD = autosomal dominant polycystic kidney disease; CKD = chronic kidney disease; FSGS = focal segmental glomerular disease; ACEi = angiotensin converting enzyme inhibitor; ARB = angiotensin receptor blocker; MDRD = Modification of Diet in Renal Disease; eGFR = estimated glomerular filtration rate; BMI = body-mass index; SBP = systolic blood pressure; DBP = diastolic blood pressure. The gene discussed is ACE; the disease is focal segmental glomerulosclerosis.