Although the increased risk for thrombotic events in PV patients with anti-PF4/heparin IgG is statistically nonsignificant in our cohort, a subtle but relevant contribution of anti-PF4/heparin IgG to thrombosis in PV cannot be excluded at this point, particularly in view of the multifactorial nature of thrombosis in MPN with hematocrit and leukocyte levels as major risk factors. Here, PF4 is linked to myeloproliferative disorder.