Condezo-Hoyos et al. [448] measured an array of oxidative stress biomarkers (SH, GSH, UA, ORAC, MDA-bound protein, protein carbonyls, AOPP, 3-nitrotyrosine, CAT, XO, and MPO) in patients with chronic venous insufficiency (CVI) and used for the OXyVen index calculation the normalized and standardized plasma parameters which showed a significant statistical difference between CVI patients and controls (SH, MDA-bound protein, protein carbonyls, and CAT activity). This evidence concerns the gene CAT and chronic venous insufficiency.